Cogent Skills Apprenticeships : MedImmune - ATA Level 5 Technician Scientist Apprenticeship Oncology
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This role offers an opportunity to learn side-by-side with a diverse team of cancer and immunology experts at the cutting-edge of research. You will receive extensive training for all aspects of the role, and will be assigned your own mentor to provide help and advice during your time at MedImmune. In addition, you will be supported and funded to undertake an accredited degree course part-time whilst working. This is an amazing opportunity to work in industry-leading laboratories at the cutting edge of drug discovery.
MedImmune Oncology has a pipeline of candidate therapies aimed at enhancing the immune response to cancer. Such “immuno-oncology” (IO) approaches have recently emerged as the most promising breakthrough in cancer treatment and is central to MedImmune’s Oncology strategy.
To better model how IO drugs interact with a patient’s cancer cells and immune system, we have developed an in vitro assay based on the culture of human tumour samples. The tissue slice culture platform captures the complexity of the tumour microenvironment in its original 3D context and is viewed as a patient-relevant system to test drugs and enable development of cancer medicines.
You will learn side by side within a diverse team of experts at the cutting-edge of research and development in this exciting field. In this role, you will learn how scientific research is executed in an industry setting to deliver meaningful data to help guide early stage drug discovery and later stage development of new medicines.
You will design and execute experiments to support our understanding of the biology of our drug candidates. Following extensive training, and with continued support, you will be expected to prepare protocols, execute experiments, analyse data, interpret results and summarise finding in reports and presentations with minimal supervision. You will also work effectively within the wider department and contribute to one or more project teams, whilst continuing to broaden your scientific expertise through interactions with other members of the oncology team.
- You will carry out a wide variety of scientific techniques routinely used in drug discovery and fundamental cell and molecular biology. Specifically, use of a unique in vitro assay system, the tissue slice culture, will be central to the role.
- Core techniques include:
- Tissue culture –culture of tumour slices, aseptic technique, cell counting, drug treatments, maintaining cultures, microscopy etc.
- Biochemical assays – protein analysis, cell viability readouts, antibody conjugation.
- Molecular biology – mRNA extraction, quantitative RT-PCR.
- Multiplexed cellular readouts – Flow cytometry, fluorescence microscopy including live imaging of tissue sections.
- Human tissue activities - handling and tracking human patient samples
- Other standard operating procedures where appropriate.
- Rigorous data management and analysis to support the lab-based techniques will also be key to the role.
Role specific technical ability:
- Once trained, to demonstrate technical competence in the use of specified instruments and equipment Standard Operating Procedures.
- To diligently apply knowledge learned during training and continued use.
Role specific competencies:
- Ex vivo culture establishment and maintenance following agreed research plan.
- Handling and tracking of human biological samples (HBS).
- Manage reagent preparation and culture treatments for experiments.
- Manage reagents and consumables to ensure sustainability.
- Logical experimental design capabilities and ability to analyse and interpret results
Will possess 3 A levels (or equivalent), two of which must be in a science subject (ideally biology) at grade B or above. Five GCSE’s at grade C and above including Mathematics, Science and English (or equivalent).